Projects

Baltic -German University Liaison Office project "Translation of fiber-based molecular spectroscopy to in situ analysis of pancreatic tumor tissue" (Agreement No. 2024/), supported by the German Academic Exchange Service (DAAD) with funds from the Foreign Office of the Federal Republic Germany, 7773,00 Eur, project leader V. Šablinskas, 2024.

This research project aims to transfer new developments in fiber-based infrared (IR) spectroscopy from Vilnius University for in situ detection of pancreatic cancer. Using histologically characterized tissue thin sections of human primary tumors, a differentiation from normal tissue will be achieved. The investigations will be transferred to in-situ measurements at the clinic in Dresden and will initially be performed on freshly resected human tissue in the operating room.

The project is financed through: Baltic-German University Liaison Office, Z. A. Meierovica bulv. 12, Rīga, LV-1050, Latvia.

Researcher groups project of Research Council of Lithuania „Evolution of optical excitations in heterogeneous molecular compounds“, Nr. S-MIP-20-47.

150000 Eur, 2020–2022.

Aggregates of molecular pigments are efficient sxcitation energy transporting units, they perform charge separation and in some cases mediate charge transport in photovoltaic and OLED applications. These processes are very complex on microscopic scale, hence, their control and optimization requires quantitative level theoretical understanding. Often the optimal interplay of quantum coherences and dissipation processes is responsible for the functionality, e. g. it has been demonstrated that molecular vibrations actively participate in energy relaxation and charge separation processes in organic solar cells and in pigment-protein complexes in photosynthesis. Even more complex are heterogeneous systems, where the energy separation between different electronic states is larger than the typical phonon energies. Inter-mode couplings, vibrational anharmonicities and nonlinear coupling to electronic states mediate the energy relaxation and conversion processes. Theoretical description of energy relaxation and conversion processes will be developed within the project for the purpose of developing computer simulation approaches for nonlinear optical spectroscopy signals of such systems at various temperatures, what is commonly studied experimentally. For this purpose n-particle quantum approaches together with time dependent variational principle will be used to optimize many-body wavefunction of the quantum system. As a result, the properties of exciton energy migration facilitated by molecular vibrations will be better understood. The proposed research will contribute to general development of theoretical understanding of physical processes on molecular scale what is necessary for developing molecular designs in industry. The proposed activities will contribute to top-level research in the region and widening of experiences of project participants.

Baltic -German University Liaison Office project "Fiber ATR FTIR spectroscopy: towards in vivo studies" (Agreement No. 2019/10), supported by the German Academic Exchange Service (DAAD) with funds from the Foreign Office of the Federal Republic Germany, 5000 Eur, project leader V. Šablinskas, 2019.

The aim of this project is to develop strategies how fiber-based molecular spectroscopy can be translated into intraoperative application in order to improve the diagnosis and finally the prognosis for the patient. During the project portable fiber optic spectrometer and special algorithms of statistical analysis will be used for obtaining and processing of the spectra.